---

RELATIONSHIP OF RETINOL BINDING PROTEIN-4 WITH INSULIN RESISTANCE, LIPID PROFILE AND BODY MASS INDEX

Bushra Noreen* 1, Muhammad Imran Khan 2, Muhammad Shahid Qureshi 3, ZainabIqbal 4, Sadia Sabahat 5, Aroosa Waheed 6, Faheem Hadi 7, Tahir Maqbool* 8

---

Download PDF

---

ABSTRACT

Background:Retinol Binding Protein 4 (RBP-4) is an adipokine, RBP-4 was identified as key regulator of obesity related insulin resistance and type 2 diabetes, and certain components of metabolic syndrome. RBP4 is secreted mostly by liver and adipocytes.RBP-4 is a member of lipocalin family transporting vitamin A from liver to peripheral tissues.RBP-4 is linked to obesity and its comorbidities especially insulin resistance, type 2 diabetes, and certain components of metabolic syndrome.The present study is aimed to assess serum level of RBP4 and its correlation with insulin resistance in patients with visceral obesity and type 2 diabetes mellitus.

Methadology:For the current study forty eight men (n=48) and thirty two women (n=32) age and sex matched controls were substituted. All of the research work was carried out after the approval from the research ethical committee of the Institute of molecular biology and biotechnology (IMBB), The University of Lahore. An informed consent was obtained from the patients before including them into the study. Five ml of blood was taken from cubital vein and stored at -70^oC for further analysis. The samples were processed and analyzed for the estimation of LDL/HDL, VLDL and Triglycerides with the help of their respective methods.

Results:The demographic data of the cohort is shown in table 1. The cohort was composed of men (n=48, 54%) and women (n= 32, 46%) with mean ages of 33.64 ± 12.08 and 31.50 ± 20 years respectively.  Means and medians of BMI, waist circumference, fasting blood sugars, serum insulin, HOMA-IR and serum RBP4 levels are also shown. All the above-mentioned variables were skewed as shown by Shapiro Wilk test (p≤0.05). Conclusion:The current study demonstrated the value of RBP4 as an indicator of insulin resistance in type 2 diabetes and viscerally obese subjects as it was found high in viscerally obese group as well as in diabetics. Also, RBP4 had significant positive correlation with FI & HOMA-IR in the viscerally obese group, so it may be a risk factor for type 2 diabetes in this group.

Keywords: Type2DiabetesMellitus Low Density Lipoproteins, High Density Lipoproteins, Very Low Density Lipoproteins, Triglycerides