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THERAPEUTIC EFFECTS OF CINNAMOMUN ZEYLANICUMON BARK ON HYPERLIPIDEMIA IN HYPERCHOLESTEREMIC RATS

Sadaf Faiz, Ahmed Umer Sohaib*, Ezzah Tariq, Tassawer-e-Meran, Atta -ur-Rehman

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ABSTRACT

Background: Cinnamon is one of the most important spices used daily and regularly by humans everywhere in the world.

Aim: The aim of this study was to evaluate the anti-obesity effect of cinnamon bark.

Objective: This research was conducted to find the pharmacological effect of cinnamon bark on hypercholesteremia and to evaluate its anti-obesity effects.

Methodology: Cinnamon bark extraction was obtained from the maceration technique. Cinnamon bark powder (30 g) was extracted with acidified methanol (100 ml) 4 times, successively 4h, 12h, 4h and 12h. The centrifuge supernatants were combined, and the methanol was evaporated in vacuum at 30°C.The residue was dissolved in water and lyophilized to obtain cinnamon powder.

Results: The most essential findings of this examination were that extract of cinnamon powder at doses of 2 g/kg consistent with day for 35 days decreased body weight, total serum cholesterol, triglycerides, and LDL levels, while levels of HDL increased compared to those of the treated control (institution D) in hyperlipidemia grownup male rats.

Conclusion: In this study, it was discovered that methanolic extract of Cinnamomum showed significant anti-hyperlipidemic effects in adult male rats. A significant decrease was observed in BMI measurements, blood glucose degree analyses, serum triglyceride analyses, serum LDL analysis, serum HDL evaluation, and serum LDL cholesterol assessment.

Keywords: Body mass index, cinnamon zeylanicum, obesity, weight loss